I would like to add a few comments to Johannes excellent post.
1) For clients using mEIII or mEIV and CLIO (which is now discontinued) your processing needs are still being met. The mE5 marathon FPGA is faster and has more resources than the mEII/mEIV + CLIO combined!
2) mE5 marathon under the latest Runtime is Windows 10 certified... so a validated path to upgrading not only your frame grabber hardware but also your Windows OS for your systems!